Posted by SLS on July 6, 2019, at 22:47:58
In reply to Re: IV Ketamine, not nasal spray, posted by Stargazer2 on July 5, 2019, at 0:06:31
> How would Ketamine be administered at home. Who would prescribe it for anyone unless you can get it somehow directly and even still how would you administer it?
A doctor can prescribe ketamine as a solution to be prepared by a compounding pharmacy and delivered in a nasal spray container.
Scientific studies evaluating the efficacy of intranasal ketamine in the treatment of depression are inconsistent. Some report success. Others report failure. I recall seeing somewhere that some people who fail to respond to intranasal go on to respond to I.V. I would be interested to know if anyone claims to be certain that intranasal ketamine is useless. Dosage is very important, and it must be finessed. A dose that is too high doesnt work according to John Krystal. Perhaps this is why the results with I.V. are more consistent than those with intranasal. The amount of ketamine reaching the brain using I.V. is presumably controlled better.
I know someone who responds to monotherapy intranasal ketamine who had not done well with any other antidepressants. After her third day of ketamine treatment, she described her response as being robust, and even used the word "remission" shortly thereafter. She no longer uses such optimistic words, but she is significantly better than she was. However, she is inconsistent in the timing of her doses. I tried intranasal ketamine a number of years ago using daily dosing. It had no effect. In retrospect, I think I should have tried a different pharmacy. I think most people dose intranasal ketamine once every 5 days.
Have you heard anything about hydroxynorketamine (HNK)? It is a metabolite of ketamine that can be given orally. It is not supposed to have psychotomimetic or dissociative side effects.
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1104648
URL: http://www.dr-bob.org/babble/20190513/msgs/1105188.html