Posted by frank_23423 on April 30, 2019, at 16:55:44
In reply to Re: nardil and parnate have both pooped out on me » rose45, posted by pedr on April 17, 2019, at 9:13:18
Hi Rose,
How are you hanging in there?
You can see my post(s) from this month detailing a similar story to yours. Long story short, I did go back on Nardil and it is kicking in once again, as it has several times before in the past (almost) 20 years.
https://www.dr-bob.org/babble/20190206/msgs/1104230.html
One thing I did notice is that it did not work until I pushed it up to a max dosage. Apparently, we use higher dosages of MAOIs in the US, and most studies seem to suggest that you need .7 mg / KG of weight for Parnate and 1 mg / KG of weight for Nardil before they're fully effective.
For example, I weigh about 90 KG (thanks, Nardil :) and need 90 mg of Nardil initially and at least 60 mg of Parnate before they really kick in. Later on - after 3 months or so, I'm able to reduce down to 60 mg of Nardil or 40 mg of Parnate without sliding backwards. Anything lower, and I regress. Every week or two, I hit the max dose for a day or two, and this seems to do the trick.
MAOIs aren't like SSRIs where you take the same dose every day forever - you kind of need to max out the MAOI inhibition, then back off for a few weeks, and then hit it hard again, temporarily, etc.
Also, I was on Klonopin @ about 1mg /day for almost two months but, like you, started to rely on them too much. I was able to taper off without too many problems over about 2 weeks. There is a lot of good support over at benzobuddies.org.
Hope things get better for you!
'Frank' from the US
poster:frank_23423
thread:1103814
URL: http://www.dr-bob.org/babble/20190206/msgs/1104231.html