Posted by TH on April 16, 2019, at 15:42:41
In reply to Trancyclopromine and addiction to benzos, posted by rose45 on April 16, 2019, at 8:29:41
While Nardil does appear to appear to cause an increase in GABA, Parnate does not. Nardil's effects on GABA appear not to come directly from its role as an MAOI, but rather from one of its metabolites further downstream.
Unless there is some other mechanism for GABA down-regulation that I have neglected, it seems to me that as Parnate does not release or potentiate GABA, it should neither promote nor prevent down regulation.
Have a look at the following paper:
Insights into the Mechanisms of Action of the MAO
Inhibitors Phenelzine and Tranylcypromine: A Reviewhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1188458/pdf/jpn00047-0037.pdf
poster:TH
thread:1104006
URL: http://www.dr-bob.org/babble/20190206/msgs/1104018.html