Posted by TH on April 15, 2019, at 15:36:10
In reply to Re: Tranylcypromine Tachyphylaxis, posted by rose45 on April 15, 2019, at 7:09:11
I'm not a doctor and really have no place making suggestions, but if it were me in that position here's what I would be considering:
I would either take a higher dosage of an MAOI, and tolerate the side effects for the adjustment period in the hopes that they lessen with time, adding lithium / lamotrigine if that "high" feeling started to return;
Or I would be considering looking for a new antidepressant medication regime that didn't act on dopamine. The dopamine receptors certainly are known for being involved with things like reward seeking and risk taking so it doesn't seem too far-fetched of an idea. Maybe Clomipramine, as a potent SNRI, would be an appropriate choice? It also has a non-narcotic sedative effect so taking the dose at night could help with sleep.
poster:TH
thread:1103943
URL: http://www.dr-bob.org/babble/20190206/msgs/1103987.html