Posted by Jeroen on March 8, 2019, at 10:00:59
I dont know what it is just found it on this link i quote https://www.ncbi.nlm.nih.gov/pmc/articles/PMC181192/
More recently, cycloserine, a second-line agent in the treatment of TB, has received attention as a potential therapeutic agent for the negative symptoms of schizophrenia. Two placebo-controlled studies40,41 have indicated that cycloserine improves the negative symptoms of schizophrenia when used alone or with traditional neuroleptics. This improvement is thought to occur by the action of cycloserine on the glycine modulatory site of the N-methyl-d-aspartate receptors. The use of cycloserine alone does not appear to be a viable clinical option, since cycloserine is not believed to improve the positive symptoms of psychosis.41 Preliminary evidence has indicated that the appropriate dose of cycloserine for the treatment of schizophrenia is in the range of 50 to 100 mg/day.4042 Larger doses of 250 mg/day and 1 g/day have been associated with anxiety, irritability, and depression.43,44 Cycloserine may be contraindicated in combination with clozapine. Two placebo-controlled trials45,46 in which cycloserine was used as an adjunct to clozapine indicated a worsening of negative symptoms when the 2 drugs were used in unison. Although further study is required, cycloserine appears to offer a moderate improvement in negative symptoms when used in a narrow dose range and with the appropriate antipsychotic agents.
poster:Jeroen
thread:1103544
URL: http://www.dr-bob.org/babble/20190206/msgs/1103544.html