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Re: Let's talk about combing SSRIs and TCAs » SLS

Posted by TriedEveryMedication on June 23, 2018, at 0:33:55

In reply to Re: Let's talk about combing SSRIs and TCAs, posted by SLS on June 23, 2018, at 0:15:03


> Moclobemide monotherapy is not terribly impressive as an antidepressant. Many people experience a very strong therapeutic effect during the first week at low dosages. Very few side effects are reported.

funny you mention this. I've experienced just that on moclo... I wonder if there's a way to reset that therapeutic action, the way some augmenters can reset ssri poop out.


> I am currently mixing nortriptyline with Trintellix (vortioxetine). If that doesn't work, I will combine nortriptyine with Effexor (venlafaxine). I received a partial response from this combination, but at dosages that were too low. I expect that I will need a minimum of 300 mg/day of Effexor with 100 mg/day of nortriptyline. I am also taking lithium, prazosin, and Lamictal now. I wasn't taking these drugs during my previous Effexor/nortriptyline trial. I would consider taking Abilify or Latuda if necessary.
>
> I am open to all suggestions. I could use a few more.
>


I've tried these: vortioxetine + desipramine. paroxetine + desipramine. effexor + desipramine. prozac + desipramine. I think out of that bunch, prozac + desipramine works the best. I definitely feel better, though I feel like I could feel even better and I've hit a plateau. Only real problem with this combo as I mentioned before is potential QTc prolongation. effexor + desipramine seemed to work, but my mood would crash towards the end of the day.


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poster:TriedEveryMedication thread:1099256
URL: http://www.dr-bob.org/babble/20180521/msgs/1099266.html