Posted by SLS on April 16, 2018, at 22:29:42
In reply to Re: Buspirone causes insomnia? » SLS, posted by linkadge on April 16, 2018, at 13:44:59
> Hi SLS,
>
> Yes, I have experienced insomnia from buspar (in fairly low doses). However, the insomnia effect did subside to some degree over time.Thanks, Linkadge
I read that at low dosages, buspirone preferentially antagonizes dopamine presynaptic autoreceptors, which was reported to increase DA activity and NE activity. I wonder if it was the 1PP metabolite responsible for the increase in NE activity via NE alpha-2 receptor antagonism. However, the increase in NE could be a downstream consequence of DA increase. Either way, low dosages of buspirone produced insomnia or sleep disturbances. I like that idea. Insomnia has been a good prognosticator of an eventual robust response for me.
https://www.ncbi.nlm.nih.gov/pubmed/19024168
https://www.ncbi.nlm.nih.gov/pubmed/2350096
https://www.ncbi.nlm.nih.gov/pubmed/1883000
The third citation mirrors your description.
I am considering adding buspirone at low dosages if I end up with a partial response to Effexor. What would be an appropriately low dosage?
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1098167
URL: http://www.dr-bob.org/babble/20180331/msgs/1098179.html