Posted by bleauberry on April 13, 2018, at 8:04:40
In reply to pharmaceutical industry and their 'reinventions'., posted by Hordak on April 11, 2018, at 18:41:08
...or we could take a different approach and remove the insult causing all of the neurochemical problems in the first place....but that isn't how medicine works.....The current medical system is designed to manage illness, not to restore wellness. They are not the same thing.
Here's an example:
A girl does 20 years of bipolar-like behavior - productive mild mania alternating with sluggish withdrawal type depression. Meds help manage it all but not really. She can't decide if it's a serotonin thing, norepinephrine thing, dopamine, whatever. No idea. One day the depression takes a deeper dive. It gets really dark, with trembling, terror, schizo-like, and she says she would jump off of a skyscraper if there was one to jump off of. On day 5 of this nightmare she is offered two pills - Azithromycin (wide spectrum general antibiotic) and Rifampin (narrow spectrum antibiotic targeting tuberculosis which she doesn't have, and targets Bartonella - the bacteria from ticks notoriously responsible for psychiatric symptoms.
In less than 24 hours her psychiatric state was 70% improved. The antibiotics totally arrested the event and set her back on normal footing.
So now she is looking at a longterm journey to get better. This time she knows her prescriptions will probably come from an LLMD instead of a psychiatrist. Not that there is anything wrong with the psychiatrist. Just that, as I said, their job really is to manage illness. We want more than that. We want to restore wellness.
I used to be a King of armchair quarterbacking with receptor sites, neurochemicals, synapses, agonists, antagonists, all that. The problem is that approach rarely restores wellness with anybody anywhere.
imo
> There is a certain irony here:
>
> "Ugh, tricyclics! Low selectivity for the serotonin transporter over the noradrenaline transporter, and what's with all the antagonism at histamine, alpha and 5HT2A receptors? Dirty stuff! Thankfully this is the 90's, and we have Selective Serotonin Reuptake Inhibitors!"
>
> "...eh, maybe you do need a bit of a noradrenaline boost on top. Thankfully this is 2000, and we have SNRI's!"
>
> "...and maybe it would be nice to have some histamine/5HT2-antagonism-mediated anti-anxiety action, too. It's 2010, try some Seroquel or Mirtazapine on top of your antidepressant!"
>
> "...and we do want some alpha1-adrenergic receptor antagonism to normalize the HPA axis! And some FIASMA / BDNF would be nice. R&D, get started! It's 2018!"
>
> "...or just have a tricyclic."
>
> :=D ;=)
>
> I would not be surprised if they try to market anticholinergics as new groundbreaking anxiolytics in a few years from now... *lol*
poster:bleauberry
thread:1098091
URL: http://www.dr-bob.org/babble/20180331/msgs/1098118.html