Posted by SLS on April 9, 2018, at 22:43:48
In reply to Re: Why is alcohol the only thing that helps me? » SLS, posted by Prefect on April 9, 2018, at 21:16:47
> Aparently one severly interferences with clearance of the other:
>
> https://www.ncbi.nlm.nih.gov/pubmed/9627209
>
> But I've read positive literature about prozac/lamictal combo for depersonizaltion disorder.
>
> Why do you feel lamictal would be a good add on to luvox+abilify?I have seen Abilify + Lamictal work well for a woman with severe depression. These drugs are also critical for my feeling better (not remission yet). In my opinion, both drugs are pro-dopaminergic, albeit via different mechanisms. Abilify often acts to make SSRIs work better, so perhaps the three drugs together will help you. Lamictal is metabolized by glucuronidation, not by CYP450 enzymes, so I don't see any problems with pharmacokinetics. You might want to start Abilify at 2.0-5.0 mg/day. It is metabolized by CYP450 3A4 and 2D6. Luvox might increase blood levels of Abilify. I'm not sure. For me, 15 mg/day of Abilify is optimal, but I have bipolar depression. I had severe depersonalization and derealization earlier in the course of my illness. If depersonalization is a feature of your condition, you might need to titrate the Abilify upwards. There are reports of Abilify helping:
https://www.ncbi.nlm.nih.gov/pubmed/24992087
Keep bothering Linkadge. He knows his stuff and thinks outside the box. I'm sure he can help you.
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1098005
URL: http://www.dr-bob.org/babble/20180331/msgs/1098056.html