Posted by Tony P on March 28, 2018, at 1:03:48
In reply to Re: How do SSRIs normalise the amygdala?, posted by linkadge on February 16, 2018, at 18:33:29
A lot of meat here - thank you, linkadge. I'm bookmarking this for later reading when I'm less hypomanic!
I've thought for a long time that there must be long-term (structural) changes in the brain in response to SSRIs & other A/Ds. Otherwise how to account for the long lag in them taking full effect? When I take diazepam or Ritalin, I feel the effects within minutes, or an hour at most. Why are antidepressants different? In a few cases, (Wellbutrin/bupropion) the 7-10 days is accounted for by the buildup of its principal metabolite, hydroxybupropion. But how to explain that Prozac may take _months_ to be effective.
I'm also concerned about recent reports that long-term use of SSRIs may lead to exacerbated depression & possibly permanent changes in brain chemistry. Makes sense in terms of homeostasis, the body's tendency to rebalance -- the only question is what is the (new?) balance point.
Depression is an altered state of consciousness - SLS
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Escitalopram
Bupropion XR
Diazepam 5 mg tid - weaning
Robaxin - non-prescribed
Kava - non-Rx, prn
poster:Tony P
thread:1096983
URL: http://www.dr-bob.org/babble/20180212/msgs/1097778.html