Posted by farshad on March 25, 2018, at 17:06:47
In reply to Re: How can I block Cortisol? » farshad, posted by ed_uk2010 on March 25, 2018, at 9:52:36
> Hi,
>
> >Its not the dopamine antagonism of the antipsychotic im out for its bcus it inhibits CRH.
>
> Olanzapine (Zyprexa) acts at many receptors, so it's not possible to be so specific about why it can relieve agitation.
>
> You said you found it calming before - after a single dose, I believe? That was probably due to action at multiple receptors, and not necessarily related to CRH.
>
> >Is it just becuase it would be dangerous? Im willing to quit prami tho no problem... Im currently on 4 meds , I can quit the 3 I get online (prami, armmodafinil and selegline)
>
> Taking strange combinations like pramipexole with olanzapine is really unknown territory. You don't want to make yourself more ill.
>
> Pramipexole should not be stopped suddenly. Reduce gradually.
>
> >and I get wellbutrin from my doc . So wellbutrin + zyprexa it will be then... But i doubt I will get zyprexa...
>
> This is something you can speak to your doctor about. A lot of people find that olanzapine (Zyprexa) calms severe agitation after a small dose. Since a doctor has given it to you before, you can mention this.
>
> For schizophrenia, olanzapine is taken every day. For relief of agitation in depressive illness, it is usually short-term.
>
> A major issue with olanzapine is that some users gain a lot of weight.
>
> >So I have to do a MRI scan for the CRF1?
>
> No sorry, this wouldn't show on a MRI. Routine medical tests and scans do not show the function of this receptor.
>
> As you know, there has been research into the possible role of CRF-1 receptors in mental health conditions . Much of the research has been on rats, but there have been some clinical trials in humans. As far as I can see, some trials showed possible evidence of efficacy, whereas others did not. As an example, a trial of pexacerfont, a selective CRF-1 receptor antagonist, found that it was not effective for generalised anxiety.
>
> So, although a few CRF-1 antagonists have been developed by pharmaceutical companies such as GSK and BMS, it isn't entirely clear what they might be most useful for in humans.
>
>If I went on zyprexa since its an antagonist on the dopamine receptors and many others, would my body evnetually upregulate them? Since I heard if you use an agonist on a receptor too much your body starts decreasing the activity and if you block something too much your body starts increasing . is that true?
poster:farshad
thread:1097352
URL: http://www.dr-bob.org/babble/20180212/msgs/1097699.html