You might want to try prazosin, a NE-1a/b/d receptor antagonist. It treats PTSD and the depression and anxiety that accompany it. I am having success with it at 20 mg/day. You don't necessarily need to have classic PTSD in order for prazosin to work. A history of childhood adversity (chronic abuse and neglect) can produce C-PTSD (complex PTSD).
Alternatively, you can try propranalol, a NE beta antagonist, to reduce sympathetic activation. I don't know for certain that you can combine prazosin and propranalol together. Hypotension would be an issue. I'm guessing yes, though. Coreg (carvedilol) is a dual-action drug that combines NE beta blockade and NE alpha-1a blockade. It is used often for heart failure. If you are going to try prazosin, you must initiate treatment with a single 1 mg dose immediately before going to bed, or else dizziness and syncope can result. You can then begin to titrate the dosage upwards. You can take 2-3 mg on day 2 and go from there. Be sure to dose 2-3 times a day. Prazosin has a short half life. The only side effect I experience is a diminution of sex-drive. It is a pretty big compromise to make, but I don't have a better choice at the moment.
- Scott
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this signature | Show by default | Change to hide (next time)Some see things as they are and ask why.
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