Posted by farshad on March 17, 2018, at 12:39:49
In reply to Re: How can I block Cortisol? » farshad, posted by ed_uk2010 on March 17, 2018, at 12:15:47
> >I wanna decrease CRF1 activity.
>
> About your question. The drugs you listed aren't CRF-1 antagonists, if that helps. Blocking cortisol receptors or inhibiting its synthesis would not have the same effect as a CRF-1 antagonist. That is important.
>
> Taking a CRF-1 antagonist for depression/anxiety might be possible as part of a clinical trial. But they aren't otherwise available.
>
> I'm really not sure what you're trying to treat, to be honest. Could you give more details about your history and symptoms? I think people could offer much better advice if they knew more about you. Even leading neuroscientists only have a limited knowledge of how neurotransmitters work, so it's not possible to accurately predict medication response on this basis. Only to a vague extent.
>
> In general, psychiatry isn't particularly scientific. Not enough is understood. Medication is generally tried based on symptom clusters and likely response because there is usually no alternative method.
>
> So, what meds are you taking right now and how are you doing?
>
>
>
>Im taking some dopamine meds helps with depression and stuff not much for my social anxiety.
But these cortisol blockers I listed why wouldnt they help for an Overactive CRF1? Since they decrease cortisol which would lead to less cortisol circeling around and that would lead to CRF1 downregulation ?
I dont think I have cushings syndrome or tumours or whatever . I think I just have some mutations in my CRF1 making it overactive, here are some weird SNPs I got that I cant find any info about on the internet:
1. It says I have a mutation in my CRHR1
2. It says I have something called CRHR1-IT1 (CRHR1 intronic transcript 1) mutation (cant find anything about this)
all the info I could find about it :
Protein names
Recommended name:Putative uncharacterized protein encoded by CRHR1-IT1
Alternative name(s):CRHR1 intronic transcript 1
3. It says I have MGC57346-CRHR1 2.35 (this 1 cant find anything on either)
So you know thats a couple of mutations in my CRF1 . So my main Problem seems like a problem with the CRF1 .
So thats why I think I have too much cortisol due to CRF1 and my CRF1 has lead to an overactive ACTH.. So I dont know what to do. There is a drug called antalarmin but I dont know how to get it. there also a drug called Astressin-B which is sold in a hair product which I can get Over the counter it supposedly blocks CRH (so CRF1 and CRF2 included). that I wanna try. But im afraid it not might work since its topical and I heard it doesent cross the BBB..
poster:farshad
thread:1097352
URL: http://www.dr-bob.org/babble/20180212/msgs/1097398.html