Posted by porkpiehat on March 15, 2018, at 14:03:54
I was about to post that both Parnate and Marplan had made me into compulsively drinking, smoking, and spending introvert, with bouts of paranoia.
For the past 2.5 months I have felt out of control. I couldn't imagine not drinking and smoking a pack of cigarettes after work; or not spending every free moment preparing for a fishing trip or actually fishing. Withdrawn from friends and familiy. Feeling like people were nothing more than props in my life.
I figured I was suffering a hypomania or compulsiveness caused from dopamine stimulation from the MAOI, but I wasn't ready to give up on the benefits.
On a hunch I stopped taking the trazodone at night for sleep (it was very hard to wake up and I remember it had always caused me mid-day agitation). Since doing so the compulsive behavior and seething irritability are gone. I would rather come home and rest after work than go to the bar. I am going to stay home this weekend and do my taxes instead of driving alone 4 hours for a weekend of fishing.
HOWEVER, I am noticing a return to anxiety, mostly social, and difficulty concentrating. I wonder if there is some property of trazodone that I can satisfy in another med without causing the compulsiveness and agitation. I suspect the side effects were either from partial agonism of the 5ht1a site (buspar, viibryd, brintellix all gave me a similar detatched or irritable effect) or from the mcpp metabolite which is a messy releaser of neurotransmitters.
I'm guessing the benefits were a result of the NE alpha antagonism and/or the antagonism of 5ht2.
Nortriptyline would seem to be the best add on, but I typically don't respond well to NERInhibition.
thanks for any thoughts
poster:porkpiehat
thread:1097339
URL: http://www.dr-bob.org/babble/20180212/msgs/1097339.html