> https://en.wikipedia.org/wiki/Lumateperone
>
> It sounds pretty freakin awesome. What do you guys think?
Lumateperone is a very interesting drug. Thanks for posting the article.
What I noticed in the article:
The drug is a partial agonist of D2 autoreceptors (like Abilify), but a full antagonist at postsynaptic D2 receptors (unlike Abilify). It will be interesting to see if lumateperone is as effective for depression as is Abilify. If not, it would still be valuable to treat psychotic disorders because it appears to be less apt to produce movement EPS and akathisia side effects. It is also touted as producing no metabolic changes or weight gain.
I may give this thing a try if it proves effective for major depressive disorder or bipolar depression. My main motivation for switching from Abilify to something else is that Abilify produces major weight gain. Also, my triglycerides on Abilify is about 450 milligrams per deciliter. The normal value is 150 or less.
- Scott
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