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Re: Wellbutrin , Abilify or Remeron?

Posted by farshad on October 7, 2017, at 11:16:56

In reply to Re: Wellbutrin , Abilify or Remeron?, posted by linkadge on October 7, 2017, at 11:14:42

> Guanfacine and memantine have different mechanisms.
>
> Guanfacine is mostly to lower adrenaline release (which can reduce anxiety). Memantine is a NMDA antagonist which modulates glutamate release. It can have antidepressant / antianxiety effects.
>
> Guanfacine would likely do little / nothing for depression. Its actions are actually opposite to some antidepressants like mirtazapine (which enhances norepinephrine release via opposite activity at the same receptor).
>
> Linkadge
>
>
both guanfacine and memantine decrease amygdala acitivity.

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poster:farshad thread:1095203
URL: http://www.dr-bob.org/babble/20161215/msgs/1095231.html