Posted by JohnBoy2000 on November 4, 2016, at 3:55:29
Currently on mirtazapine and bupropion/wellbutrin.
I found wellbutrin very good at 300 mg.
450 mg it sedates me; 150 mg it's not potent enough.
300 is good, but overall, not enough.I found mirtazapine beneficial, particularly from the point of view of inducing somnolance.
I also found the higher doses more effect/sedating - I'm aware some don't find this to be the case.
And it allows me to eat - fantastic.Chronic fatigue is the main symptom, so serotonin is not effective.
I'm on the fence about dopamine thus far (effexor was previously activating at 225mg, sedating at 300mg - the dose dopamine kicks in at), but noradrenergics work, every time.So - I think replacing the mirtazapine with a more potent noradrenergic.
The names I've got so far are:
Maprotiline (tetra0
Mianserin (tetra)
Lofepramine (tricyclic)
NortriptylineThere's also the option of making the addition of a third drug to the mix, to compliment bupropion; perhaps reboxetine (listed in stahls combination treatment list), or atomoxetine.
Now - drugs.com has very few reviews of the two other tetracyclics, maprotiline and mianserin, and difficult to find information on them in general.Avoiding mACH receptors may be a preference, due to their sedating properties.
Noradrenaline is really the only neurochemical I wish to target.Anyone experienced in pharmacology or with these meds have insight?
poster:JohnBoy2000
thread:1092926
URL: http://www.dr-bob.org/babble/20160928/msgs/1092926.html