> My ADD responds really well to NRIs. Well, specifically desipramine and strattera.
>
> Problem with them (other than being on that anticholinergic list) is wicked insomnia. On them, I wake up at about 2am and can't get back to sleep until 5am.
Perhaps you should simply treat the insomnia aggressively. There have been times when I responded well to an MAOI, with or without desipramine, in which I experienced total insomnia for days and days. The best choice was to then treat the insomnia as if it were a disorder on its own. The first time, I ended up using a combination of Halcion and Ativan. I slept satisfactorily, and ended feeling well for an extended period of time. I had no qualms about taking BZDs for the long-term. I still don't. At some point, you might be able to remove the sleeping medication and remain free of insomnia.
What have you tried for sleep so far?
> I've been digging around. MAZINDOL has some NRI action but it is prescribed for obesity.
Mazindol is a failed investigational antidepressant that later was found to be helpful in obesity. I believe its main target was brown adipose tissue. There, it would increase energy production in the form of heat to regulate body temperature and burn excess white adipose tissue (fat). I don't know. Maybe it would help you, but I wouldn't invest too much optimism in it.
I am guessing that you have already investigated guanfacine?
- Scott
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