Posted by Tomatheus on March 16, 2016, at 17:41:42
In reply to Re: anti zyprexa, posted by SLS on March 16, 2016, at 15:48:43
> They should really compare MI rates between people with schizophrenia, as schizophrenia might confer an added risk, directly or indirectly.
This is a good point, Scott. The authors of the report that I read made reference to the possibility that "other unknown factors" might have affected the rates of cardiovascular disease-related deaths and diabetes in the clozapine-treated patients whose records were examined for the study. In accordance with what you said, I'd certainly think that the conditions of schizophrenia and schizoaffective disorder themselves would represent variables that might increase the risk for cardiovascular disease-related death. Knowing that the risk of cardiovascular disease-related death was higher in the clozapine-treated patients whose records were examined for this study than it is for the larger populations of both the state of Massachusetts and the U.S. is interesting, but I too think that comparing the data from this study with data from patients with schizophrenia and schizoaffective disorder who have not been treated with clozapine would have allowed for a more controlled assessment of the extent to which clozapine use might increase the risk of cardiovascular disease-related death.
Tomatheus
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poster:Tomatheus
thread:1087151
URL: http://www.dr-bob.org/babble/20160306/msgs/1087237.html