Posted by Tomatheus on March 15, 2016, at 15:05:26
In reply to Re: Inflammation-modulating chemical has AD potential, posted by Hugh on March 15, 2016, at 11:56:06
> When I suffer from an inflammatory condition, such as bronchitis, I become much more depressed. As my inflammation improves, my depression improves.
Thank you for sharing this observation with us, Hugh. I definitely find the association between inflammation and depression to be interesting. I'm not sure about the extent to which the increases in inflammation that tend occur in depression contribute to causing depressive symptoms, but I don't think that there's much question that increases in depressive symptoms and increases in inflammation tend to occur together. And considering the information in the press release that I posted indicating that the inflammation-modulating chemical TPPU prevented the onset of depression-like behaviors in mice when the chemical was administered prior to the induction of inflammation or repeated social-defeat stress, maybe it is indeed the case that reducing inflammation can have antidepressant benefits. It sure will be interesting to see if TPPU, or perhaps other soluble epoxide hydrolase inhibitors, will end up demonstrating clinically significant antidepressant properties when used in human trials.
Tomatheus
"Maybe someday
We'll figure all this out
We'll put an end to all our doubt
Try to find a way to just feel better now"- Rob Thomas
poster:Tomatheus
thread:1087149
URL: http://www.dr-bob.org/babble/20160306/msgs/1087198.html