Posted by Uncouth on March 7, 2016, at 18:29:28
In reply to Re: Nortriptyline weight gain? » Bob, posted by SLS on March 7, 2016, at 14:47:16
Hey Scott
Curious as to your experience being on both desipramine and nortryptiline. I have been on Parnate 130mg + 50mg desipramine the past month (desipramine was to replace bupropion, which I was on for a few months after strattera...) but it has not been effective. I have talked to Doc Gilman recently and he mentioned (and also has written) that people typically dramatically overdose desipramine because they compare it to other TCAs, but that if you do the math on the affinity data, you're getting total NRI at doses as low as 10-25mg--he claims desipramine is typically overdosed almost 10x.
Have you experienced marginal benefit to higher dose desipramine? I asked him point blank on Skype the other night in fact (been helping him with some other stuff for his website) whether there was any reason to go higher than 50mg on desipramine and he said "No!".
So I'm curious as to how you worked out your dosage of desipramine and what your doctor's reasoning is. And also how you can compare it to Nortryptiline.
I won't hijiack this thread but am going to post another topic about switching off of desipramine (or perhaps raising the dose if there is some reason to independent of Gilman's guidance) and i would love your thoughts on.
Also: why not just push up the Parnate as far as it can go?
poster:Uncouth
thread:1086706
URL: http://www.dr-bob.org/babble/20160306/msgs/1086861.html