Posted by J Kelly on March 2, 2016, at 19:27:11
In reply to Re: Nardil safe? » J Kelly, posted by zonked on March 2, 2016, at 17:03:01
> Hiya Jade,
>
> Parnate is an amphetamine *and* a MAOI, so the potential for psychosis could be higher than with Nardil. Nardil does have an amphetamine-like metabolite, phenethylamine, but not in worrisome amounts. Your reaction to Parnate is uncommon but not unheard of, given that it is an amphetamine (the only non-controlled substance amphetamine in the US Pharmacopoeia, AFAIK, just Rx-only.)
>
> From Wikipedia:
> "Phenelzine has also been shown to metabolize to phenethylamine (PEA).[11] PEA acts as a releasing agent of norepinephrine and dopamine, and produces effects very similar to those of amphetamine, though with markedly different pharmacokinetics such as a far shorter duration of action. Phenelzine's enhancement of PEA levels may contribute further to its overall antidepressant effects to some degree. In addition, phenethylamine is a substrate for MAO-B, and treatment with MAOIs that inhibit MAO-B such as phenelzine have been shown to consistently and significantly elevate its concentrations."
>
> The fact that Parnate (tranylcypromine) is, itself, an amphetamine (dopamine release and reuptake inhibition) combined with its MAO inhibitor action (more dopamine in the synapse) could have resulted in amphetamine psychosis, especially if you're sensitive. I am curious as to what dose of Parnate you were taking, and if you have had a psychotic reaction to any other drugs.
>
> I would not worry so much about Nardil; it's not something I've ever seen here and Nardil, as you probably know, is very popular here. I still take it, all these years later! And it STILL works!
>
> YMMV -
>
> Best,
> z
>
> > Hello all.
> >
> > The only med that ever worked on my major depression in a significant way was Parnate. However I had an unfortunate rare reaction to it years ago. I envy those who can tolerate it. Does Nardil run the same risks as Parnate re paranoid psychosis in susceptible ppl? Im remembering Ace the Nardil king and Im wondering why in all these years I did not try another MAOI.
> >
> > Hello to anyone who remembers me. I really miss some of the old posters.
> >
> > Jade
>
>
Hi Zonked :)I actually remember you... thank you so much for your response. Just the info I needed to move forward. I'm not very good at researching things when I'm depressed. So glad to hear the Nardil is working for you. I may give it a try if my pdoc agrees. He may say h*ll no and who could blame him.
As for the dose of parnate it was 80mg per day (broken up ...don't recall details) My psychosis started when my pdoc added Dexedrine. I think I got to 40mg per day. He quickly shut that down but unfortunately he and several others pdocs continued me on the parnate. I was very ill for 9 months. Two weeks off parnate I was back to reality. No episodes of psychosis before or after.
So my dilemma... parnate worked very well on my depression for a time. I'm wanting to try Nardil but frankly i'm scared.
May I ask what your dose is, how its broken up, and how long it took you to respond? How do you augment it?
Again, thank you for your thoughtful response.
Jade
poster:J Kelly
thread:1086626
URL: http://www.dr-bob.org/babble/20160131/msgs/1086651.html