Posted by SLS on January 12, 2016, at 13:26:00
In reply to Re: low dose abilify as a add-on to move my butt -Oops, posted by Lamdage22 on January 12, 2016, at 11:34:25
> http://www.drugs.com/comments/nefazodone/
>
> do you know how good this score is??I would be careful about interpreting the numbers quoted as being statistics of efficacy. I doubt 9 out of 10 people who take nefazodone attain remission. If this were true... well.
I guess you have to ask yourself what type of person would bother to write a review. Are people who remain hopelessly depressed going to have the energy or enthusiasm to do such things? I don't think so. Part of the 9.5 number for nefazodone might represent happiness with its side effect profile. I don't know. At best, the two most potent antidepressants available, Nardil and Anafranil, get 6.5 out of 10 people well who have not already demonstrated treatment resistance (TRD).
Having said all of that, I recommend that you include nefazodone on your list of things to try. It really does work for some people who are otherwise TRD. Why would any doctor or patient wish to use nefazodone as their first choice when it has the potential to cause liver failure? They wouldn't. It is much more likely that nefazodone would be chosen after other drugs have failed. So, basically, nefazodone can help people who are TRD. Just not 9.5 out of 10 of them.
Nefazodone is only a weak serotonin reuptake inhibitor, so it should not cause serotonin syndrome when combined with Effexor. I know of no contraindication for the combination. If you come across any, please let me know.
Do I recall correctly that you had a bad reaction to fluvoxamine (Luvox)? Akathisia? Fluvoxamine is supposed to have a reduced risk of akathisia compared to other SSRIs, although there are rare reports of this happening. It would be a logical choice to try fluvoxamine for psychotic depression. Perhaps this is the result of it being the only antidepressant that is a sigma-1 receptor agonist. Interestingly, sertraline (Zoloft) is a sigma-1 antagonist, and is generally thought of as being the SSRI most likely to produce akathisia. Even more interesting is that fluvoxamine has been shown to actually reverse akathisia.
http://www.annals-general-psychiatry.com/content/9/1/11
Much more information than you asked for...
By the way, I started taking resveratrol 250 mg/day.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1006480
URL: http://www.dr-bob.org/babble/20151225/msgs/1085335.html