Posted by SLS on December 14, 2015, at 5:48:40
In reply to Re: Still waiting for Vraylar (cariprazine), posted by Lamdage22 on December 14, 2015, at 4:10:51
> No idea.
>
> How high is the tardive dyskinesia risk? I may try brexpiprazole or cariprazine or both to see if they too give me akathisia like Abilify or if they are beneficial.I agree that the only way to know at this point is to try them. I don't think there is enough clinical experience to characterize the relative risk of akathisia with the two newer drugs.
I was looking at the binding profiles of all three drugs. They all do a whole bunch of things, so it is difficult for me to come to any conclusions. My remarkably uneducated guess is that brexpiprazole is less likely than Abilify and cariprazine to produce akathisia. This is based only upon their potencies as partial agonists at the dopamine D2 receptor. However, there may be some variablity in akathisia risk due to differences in serotonergic receptor activity along with the ratio of D3/D2 receptor affinities. Of course, there is the possiblity that cariprazine, being derived from a different molecular family than Abilify and brexpiprazole, acts in a manner very different and produces less akathisia than its D2 binding might indicate.
> However currently on SJW i cant sleep without a shitload of sedating pills :(Total insomnia has always been a good sign for me that I would eventually respond to treatment. I had no problem taking sleeping medication in order to live a life in a state of remission. I needed to take two benzodiazepines to be able to sleep through the night.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1084661
URL: http://www.dr-bob.org/babble/20151119/msgs/1084671.html