Posted by Lamdage22 on December 2, 2015, at 10:33:51
In reply to A few somewhat related questions. » Lamdage22, posted by SLS on December 2, 2015, at 7:17:35
> Hi Lamdage.
>
> I apologize for changing the topic somewhat.
>
> I hope these ketamine-like drugs become available quickly for you to try. If it is effective for depression, I would like to see NRX-1074 become available. It is administered orally, and is supposed to be without psychotic or dissociative side effects. Also, keep an eye out for a metabolite of ketamine, hydroxynorketamine (HNK). This orally-administered drug appears to be effective, and avoids blocking the NMDA receptor. It is without psychotic side effects. The commonality to all of these drugs is that they produce an immediate increase in BDNF production and the sprouting of neurites.> How is the buspirone working out for you?
I thought i was sleeping longer than before, so i stopped the 5mg.
> By the way, have you ever tried Abilify? I imagine you have. How did you react to it? Do you recall the dosage.
5mg. Akathisia and restlessness like crazy, so docs stopped it.
>
> Do you continue to have moderate-to-severe psychotic symptoms?No, mild if anything.
> One more question. In what ways does the high dosage of Seroquel help you?
I prefer Seroquel over Zyprexa because i think it is less likely to induce diabetes.
> One more one more question (sorry).
No problem at all. Thanks for trying to help me.Can you better detail exactly what depressive symptoms you are currently having difficulties treating? It might allow people to be of more help to you. For example:
>
> - Loss of interest in hobbies or pleasurable activities BIG TIME
> - Lack of motivation to initiate activities and get things done BIG TIME
> - Slowed movement or difficulties in initiating movement (psychomotor retardation) NO
> - Lack of mental and physical energy (anergia) BIG TIME (mental)
> - Lack of feeling pleasure or reward in doing things (anhedonia) BIG TIME
> - Reduced sex-drive NOT AT ALL
> - Slowed thoughts or cognitive impairments. Yes, cognitive impairments.
> - Memory impairments - particularly short-term memory BIG TIME
> - Difficulty reading or concentrating Yes.
> - Sadness BIG TIME
> - Insomnia - especially early-morning NOT AT ALL
> - Hypersomnia BIG TIME
> - Lack of appetite NOT AT ALL
> - Depressed mood or dysphoria BIG TIME
> - A tendency to stare into space in the absence of thought. a little bit
> - Thoughts of suicidal or self-harm a little bit
> - Agitation, anger, or irritability not really
> - Air hunger or sighing NO
> - Tearfulness NO
> - Melancholic thoughts Yes
> - Difficulty in making decisions Yes.
> - Feelings of hopelessness or helplessness BIG TIMEIt sounds quite severe to me after answering your questions
>
> I have most, but not all of these. Importantly, depressed mood, melancholy, and sadness are no longer problems for me. They were early on. Anxiety is no longer a problem for me, either. The features of depression can change over time.
>
> One more thing. I was thinking about you early this morning and your frustrations with treatment. Unfortunately, I think you will need to give medication more time to work than the average person. You may need to give most drugs a full 12 weeks to work. I have seen this occur quite a few times with people with TRD here on Psycho-Babble. My guess is that this is a function of the length of time one has been ill plus the number of drugs the brain has been exposed to. Of course, ketamine and its analogues are exceptions. At the right dosage, these drugs can make one feel better within 4 - 24 hours.
>
> The drugs I am taking help me, but are far from producing a robust improvement or remission. I am therefore using them as a bridge to the emergence of very different treatments. It's the best I can do right now. I'll take whatever I can get.Me too. I wish i was american. I would enroll in a Glyx-13 Study in a heartbeat.
>
> Currently:
>
> Parnate 80 mg/day
> desipramine 300 mg/day
> Lamictal 300 mg/day
> lithium 300 mg/day
> Abilify 10 mg/day
> prazosin 30 mg/day
>
> I just switched from nortriptyline to desipramine. It helps more with mental energy and concentration. My goal is to return to work and meet new people. I can see myself doing this if I experience a moderate improvement. With a little luck, I will feel well enough to do these things after giving this treatment a few months to work without making any changes.
>
>
> - Scott
>Good luck, Scott.
If people (even strangers) wouldnt care, the world would be a much harsher place. It makes things so much more tolerable knowing that most people want to help you.
schizo-affective, type depressive
Seroquel 700mg
Zyprexa 12.5mg
Effexor 75 mg
Metformin 2000mg
Buspar 5mg
Lithium orotate 360mg
Some Vitamin D
poster:Lamdage22
thread:1084317
URL: http://www.dr-bob.org/babble/20151119/msgs/1084338.html