Posted by SLS on November 13, 2015, at 6:36:40
In reply to Re: Novel AD in phase 3 - K-opioid receptor antagonist, posted by linkadge on November 5, 2015, at 15:28:10
> Interesting. I'm not sure how this would fare in the long term. I wonder if / how quickly the brain upregulates kappa receptors to compensate?
Wouldn't that produce a state that allows for a withdrawal rebound depression should one need to discontinue the drug? Perhaps mu recepter upregulation would compensate for this. It may be way more complicated than this, so I guess experience with the drug will ultimately be the only way to settle the question regarding withdrawal.
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1083845
URL: http://www.dr-bob.org/babble/20150929/msgs/1083981.html