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Re: Fluvoxamine Saphris Interaction

Posted by phidippus on October 30, 2015, at 22:58:18

In reply to Fluvoxamine Saphris Interaction, posted by MuseMemento on October 19, 2015, at 16:05:27


The CYP1A2 inhibitor fluvoxamine, can alter the metabolism of asenapine.

at a dosage of 25 mg twice daily for 8 days and one dose of asenapine 5 mg increased the Cmax of asenapine by 13%; therefore, the manufacturer recommends coadministration with caution


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