Posted by former poster on September 27, 2015, at 23:45:20
Why don't Doctors prescribe Savella (Milnacipran) for social anxiety?
"Conditioned fear stress (CFS)-induced freezing behavior has been proposed as an animal model of anxiety especially social anxiety. CFS-induced freezing is attenuated by the acute administration of milnacipran as well as the SSRIs, citalopram and fluvoxamine, whereas the selective NE reuptake inhibitor, maprotiline, was inactive (Hashimoto et al 1996). These results suggest an important role for the facilitation of 5-HT neurotransmission in the reduction of CFS-induced freezing behavior. A study in an analogous model in mice showed similar results with milnacipran and fluvoxamine inhibiting conditioned fear stress induced freezing behavior to a similar extent (Miyamoto et al 2004)."
poster:former poster
thread:1082969
URL: http://www.dr-bob.org/babble/20150901/msgs/1082969.html