Posted by phidippus on August 6, 2015, at 17:27:51
In reply to Re: does lamotrigine cancel out dexedrine? » phidippus, posted by SLS on August 5, 2015, at 23:46:59
>How do you interpret the article you cited?
Mostly what I come away with was LTG caused a supression of DA and 5ht with single administration, whereas long term administration led to an influx of 5ht and dopamine. This is simplified...
>The article you cited provides no mention of the nucleus accumbens. I think you will find that glutamate antagonizes dopamine circuits there.
I can't find anything about the relationship between dopamine and glutamate in the nucleas accumbens.
Perhaps LTG helps with depression simply by antagonizing glutumate.
Eric
poster:phidippus
thread:1080542
URL: http://www.dr-bob.org/babble/20150806/msgs/1081082.html