Posted by linkadge on June 7, 2015, at 12:04:17
In reply to Re: Replay: High cortisol = poor response to Prozac » Christ_empowered, posted by SLS on June 6, 2015, at 13:27:02
Yes, in general serotonergic agents do increase cortisol. I think the effect is mediated (in part) by 5-ht2 receptors. Reciprocally, cortisol increases the sensitivity of 5-ht2 receptors.
Some studies suggest a desensitization and / or normalization of cortisol over time, but others do not.
In general, agents with block 5-ht2a act as anti-cortisol agents. For instance, remeron, cyproheptadine, amitriptyline, seroquel etc have all been independently shown to decrease cortisol. In fact, cyproheptadine is a treatment for Cushings disease, characterized by hyper secretion of cortisol. Some of the antipsychotic (and perhaps augmentative) effect of atypicals is mediated by 5-ht2a.
poster:linkadge
thread:1079501
URL: http://www.dr-bob.org/babble/20150520/msgs/1079520.html