Posted by ihatedrugs1 on June 1, 2015, at 13:13:17
In reply to Re: Latuda. Need advices please! » ihatedrugs1, posted by SLS on June 1, 2015, at 9:36:55
> > A couple of years ago, I tried Remeron again, but it didn't do anything for depression nor help as a sleep aid like it did before.
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> Most doctors are clueless as to the true therapeutic dosage range for Remeron when treating severe depression. In my opinion, 45 mg/day is the minimum. Most doctors stop at 30 mg/day. Dumb. You don't start getting the antidepressant effect that comes from NE alpha-2 blockade at low dosages. Remeron is almost exclusively antihistaminic at dosages less than 45 mg/day. It does block a few serotonin receptors, but hypersomnia and hyperphagia prevail. Interestingly, there is a tendency for both of these effects to wane as the dosage is increased. In other words, although possibly effective for you, Remeron had no chance of working at low dosages.
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> Has the bipolar spectrum ever been discussed with you as a possible diagnosis?
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> If you were responsive to treatment at one time, I would not capitulate to pessimism or cynicism just yet. Even when you lose optimism, resilience, and positive energy, try to be constructive rather than ruminating and projecting negative energy. It might help you from finding yourself in dark places.
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> Don't give up.
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> I am doing pretty well so far today (all things considered). Thanks for asking :-) I am grateful for a reprieve from the worst of it.
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> - ScottI have been evaluated for Bipolar spectrum but do not fit the bill. I only get depressed, never manic. I'm wary of Remeron's weight gain side effect, even though it's supposed to be less likely at higher doses. I'm pre-diabetic and need to stay as healthy as I can. The last thing I need is more health problems.
I'm feeling a little better each day; hopefully, it'll continue. However, if things don't improve to my expectations, I will consider discussing adding Remeron at a higher dose with my pdoc or increasing Effexor.
I try to stay positive. It's just hard when I experience no enjoyment at all. I recently came from vacation to Paris and Spain and was unable to enjoy it. I'd observe other people's ease and happiness, including my family's, and it felt so foreign. I had to pretend amusement for my family's sake. That is what gets to me most. I used to find joy in even the smallest of things. Can't wait for that feeling to return.
In the meantime, it's just another waiting game.
I want to thank you for always being so generous with your advice. I think I can speak for everyone in this forum when I say that your insight and contributions are highly regarded and helpful to many of us.
I'm glad you're feeling better.
Well wishes,
ihatedrugs
poster:ihatedrugs1
thread:1079315
URL: http://www.dr-bob.org/babble/20150520/msgs/1079369.html