Re: Possible drug approaches to hit Glutamate? » kilo8

Posted by phidippus on May 13, 2015, at 12:16:58

In reply to Re: Possible drug approaches to hit Glutamate?, posted by kilo8 on May 12, 2015, at 19:02:13

While pregabalin is a structural derivative of the inhibitory neurotransmitter gammaaminobutyric acid (GABA), it does not bind directly to GABAA, GABAB, or benzodiazepine receptors, does not augment GABAA responses in cultured neurons, does not alter rat brain GABA concentration or have acute effects on GABA uptake or degradation. However, in cultured neurons prolonged application of pregabalin increases the density of GABA transporter protein and increases the rate of functional GABA transport.

There is no way to conclude from symptoms whether you have excessive glutamate.
Eric

Thread

Possible drug approaches to hit Glutamate? kilo8 5/5/15
Re: Possible drug approaches to hit Glutamate? burial 5/6/15
Re: Possible drug approaches to hit Glutamate? SLS 5/6/15
Re: Possible drug approaches to hit Glutamate? Bill82 5/6/15
Re: Possible drug approaches to hit Glutamate? kilo8 5/7/15
Re: Possible drug approaches to hit Glutamate? Bill82 5/7/15
Minocycline you forgot.... Jeroen 5/7/15
Re: Possible drug approaches to hit Glutamate? » kilo8 phidippus 5/7/15
Re: Possible drug approaches to hit Glutamate? porkpiehat 5/8/15
Re: Possible drug approaches to hit Glutamate? kilo8 5/9/15
Re: Possible drug approaches to hit Glutamate? » kilo8 phidippus 5/9/15
Re: Possible drug approaches to hit Glutamate? Bill82 5/12/15
Re: Possible drug approaches to hit Glutamate? kilo8 5/12/15
Re: Possible drug approaches to hit Glutamate? » kilo8 phidippus 5/13/15
Re: Possible drug approaches to hit Glutamate? kilo8 5/15/15
Re: Possible drug approaches to hit Glutamate? » kilo8 phidippus 5/18/15
Re: Possible drug approaches to hit Glutamate? kilo8 5/25/15
Re: Possible drug approaches to hit Glutamate? » kilo8 phidippus 5/27/15
Re: Possible drug approaches to hit Glutamate? kilo8 6/11/15
Re: Possible drug approaches to hit Glutamate? » kilo8 phidippus 6/12/15
Re: Possible drug approaches to hit Glutamate? kilo8 6/12/15

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