Posted by linkadge on April 3, 2015, at 14:39:53
In reply to Re: Ketamine and ketamine-like drugs » linkadge, posted by europerep on April 3, 2015, at 7:37:32
One of the targets of ketamine is GSK3. GSK3 is also inhibited by lithium and zinc, which can have rapid antidepressant effects.
That being said, GSK3 interacts with serotonin. Low serotonin levels dysregulate GSK3 which can be reversed by increasing serotonin (i.e. SSRIs) or GSK3 inhibitors.
What I am getting at, is that it may not be that ketamine has a different target. It may simply by that ketamine affects a target that other antidepressants take longer to regulate.
http://www.sciencedaily.com/releases/2014/01/140107102442.htm
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200424/
Linkadge
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