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Re: Low dose antipsychotics increase dopamine?

Posted by Christ_empowered on March 30, 2015, at 9:07:32

In reply to Low dose antipsychotics increase dopamine?, posted by Chinaboy on March 27, 2015, at 23:22:02

Low doses of some antipsychotics (even old ones, weirdly enough) can be somewhat stimulating. Problem is...that effect is often short-lived. Some people on amisulpride, for instance, notice that it kind of "poops out" after a while.

Anyway, the Prozac+Zyprexa combo (symbyax here in the US) has been studied, since it is/was patented. You can google it if you want..I think that at some doses it can increase dopamine concentration in some parts of the brain.

In the US, symbyax comes in several different combos/ratios, all the way up to 12/50 (12 zyprexa, 50 Prozac). The lower doses are comparable to what you've been prescribed...3/25 or something like that.

Anyway, varying doses of neuroleptics can be used with more stimulating AD drugs for a while to keep people from freaking out. They can also be used w/ psychotic depression for a time and then tapered when the psychosis and agitation subside. So....my best guess is that with both wellbutrin AND Prozac on board, the zyprexa will, if nothing else, keep you calm(er) while you adjust to the meds (which, btw, are full dose...I guess your doc doesn't do slow titration?).

I'd do a drug interactions check if you're worried. I go to community health and to save time and money, they'll pull stuff like your doc did...put somebody on a little cocktail w/ full dose meds right off the bat, then its "see you in 8-12 weeks!," and they're done. I just find it a bit unusual that a private practice doc would do that, but...whatever.

Good luck!


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