Posted by rjlockhart37 on December 30, 2014, at 22:52:34
In reply to Re: norephrinephrine, posted by joe f on December 30, 2014, at 7:00:37
i've read that in some articles about prozac.....this is a one of some info i found on crazymeds site, written by another poster
"something else: on the main site it is stated more than once that Prozac (fluoxetine) is the weakest SSRI. I don't think this is correct either. Prozac is not the weakest but the least selective SSRI. Even so, its metabolite norfluoxetine is more selective and also a stronger serotonine reuptake inhibitor than fluoxetine itself, as stated in an article: 'Fluoxetine is the least selective and the metabolite of fluoxetine, norfluoxetine, is a more selective and more potent 5-HT reuptake inhibitor than the parent compound and has an extremely long half-life (715 compared to 13 days). Thus the metabolite plays an important role for the therapeutic effect of fluoxetine.' In terms of potency as a 5 HT reuptake inhibitor, fluoxetine ranks fourth among all SRI-meds; it has lower potency than paroxetine and sertraline, but higher potency than citalopram, imipramine and fluvoxamine. Fluvoxamine is actually the weakest SSRI in terms of 5 HT reuptake inhibition; its mechanism of action might depend heavily on sigma-1 agonism. Though not a true SSRI, venlafaxine is even weaker
another site
"Among SSRIs, 'fluoxetine is the least "selective" of all the SSRIs, with a 10-fold difference in binding affinity between its first and second neural targets (i.e., the serotonin and norepinephrine uptake pumps, respectively)"
http://flipper.diff.org/app/items/5558also found these sites too on potency of SSRI's but mainly their percetage ratings on serotonin
http://www.emedexpert.com/compare/ssris.shtmland this is a post by me in early 2008 under one off my previous screennames
http://www.dr-bob.org/babble/neuro/20080114/msgs/807847.html
things have changed alot since then, prozac started to adapt to my body and the resistance from my body made not as euphoric like i was back then.....i was boppdy doobob back then, noww it's more of a gloomy period....one more thing i think that points everything out is...the least selective targets more other nuero's than just one receptor site, lexepro is the most selective and it only works on certain serotonin sites, which prozac works on more sites including dopamine and NE indirectly.....i think thats what it means....
"The least selective SSRI is fluoxetine which has some dopamine and noradrenaline reuptake blocking effect. (29)"http://www.benzo.org.uk/ssri.htm
love google
r
not a scholar but understand distress.....
"unheard pain, is the told through good company"
poster:rjlockhart37
thread:1074557
URL: http://www.dr-bob.org/babble/20141120/msgs/1074624.html