Posted by SLS on December 27, 2014, at 8:09:43
In reply to Re: Rozerem - Update, posted by vbs on December 27, 2014, at 7:29:19
> I took trazodone last night in order to fall asleep. No voices. Voices are episodic. I think that trazodone treats underlying agitation that is like atypical anxiety. I will resume trazodone 100 mg.
Trazodone has a metabolite known as mCPP (m-chlorophenyl-piperazine) that acts as a serotonin 5-HT2c receptor agonist and 5-HT2b receptor antagonist. Not good. mCPP is known to be anxiogenic. My guess is that the degree to which someone experiences anxiety with trazodone is dependent upon their sensitivity to mCPP, dosage, metabolic rate, and timing post-dose. Hopefully, you can find the ideal lowest dosage of trazodone that does the job.
Have you ever thought to try low dosages of Remeron (7.5 - 15.0 mg) taken at bedtime? A little 5-HT2a/c antagonism along with histamine H1 antagonism might help with sleep and anxiety.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1074510
URL: http://www.dr-bob.org/babble/20141120/msgs/1074522.html