Posted by tom2228 on December 20, 2014, at 12:12:09
In reply to Re: ssri's-serotonin only, posted by rjlockhart37 on December 20, 2014, at 10:22:47
Lexapro is the most selective SSRI for serotonin that's on the market. It is closest you can find to a pure 5-HT reuptake inibitor.
Celexa is a close second but has slight antihistamine action. Perhaps this would be best for minimizing activation if you can't go for Luvox -- or maybe Paxil?
Luvox: additional blockade of sigma-1 receptor (more strongly than that of Zoloft)
Paxil: additional effets on muscarinic acetylcholine receptors, slight NE reuptake inhibition, and inhibition of nitric oxide synthase
Zoloft has additional effects on sigma-1 receptors and is a slight dopamine reuptake inhibitor. I found it pretty peaceful but kind of jittery, although this isn't the same as the activation I experienced on Prozac.
Prozac additionally blocks 5-HT2c receptors and slightly inhibits NE reuptake. Activating but less peaceful and clear than Zoloft; more stimulating; more "comfortable" but more busy in the mind.
But remember these neurochemical properties do not necessarily equate to the preconceived notions we have about neurotransmitter "feelings" when it comes to how the drug will feel for us.
Here's more information on their comparative mechanisms of action--
--complicated: http://www.preskorn.com/books/ssri_s3.html
--more simple: https://books.google.com/books?id=BBtMzTV8OMgC&pg=PA296&lpg=PA296&dq=ssri+differences+stahl&source=bl&ots=HforscSoMW&sig=vEcJlb18eYiSWRFBdnMExeP5kNU&hl=en&sa=X&ei=p7iVVJqRNsKvggSvqILICA&ved=0CDEQ6AEwBQ#v=onepage&q=ssri%20differences%20stahl&f=falsecomparison of most-prominent side effects and efficacy:
http://www.preskorn.com/books/ssri_s5.html
poster:tom2228
thread:1074367
URL: http://www.dr-bob.org/babble/20141120/msgs/1074386.html