Posted by SLS on December 12, 2014, at 20:13:12
In reply to Re: Trying low-dose naltrexone (LDN)., posted by baseball55 on December 12, 2014, at 19:51:09
> I don't really understand LDN. Naltrexone blocks opiate receptors so that opiates have no psychological affects. I took 50mg for a year after I withdrew from opiate addiction. My husband gave it to me every night.
>
> I drank while taking it. It did not in any way change my response to alcohol. Why would it? Alcohol doesn't bind with opiate receptors. I know a lot of alcoholics and none of them had a response to naltrexone.
>
> So, 1/10 the dose for depression. What's the theory here?That's a good question.
I'm not totally sure. If it works anything like certain antipsychotics (sulpiride; amisulpride) do on dopamine, it has opposite effects at low dosages due to the suppression of the negative feedback loop that would otherwise suppress neurotransmitter manufacture and release. I really should look into it. Thanks for motivating me.
:-)
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1074164
URL: http://www.dr-bob.org/babble/20141120/msgs/1074182.html