Posted by SLS on December 10, 2014, at 21:32:03
In reply to Re: Starting Cymbalta, how much til it helps pain? » pattisun16, posted by phidippus on December 10, 2014, at 13:23:23
I might be misremembering, but I think the antidepressants that have the best antinociceptive properties are reuptake inhibitors of both serotonin (5-HT) and norepinephrine (NE).
http://www.sciencedirect.com/science/article/pii/S0028390804003156
I don't know why imipramine and clomipramine do not have reputations for treating pain. There is still much to learn about what these drugs do in the poorly understood brain. Elavil (amitriptyline) and Cymbalta (duloxetine) are the antidepressants best known to be antinociceptive, although fluoxetine (Prozac) is occasionally mentioned. Check out milnacipran, another reuptake inhibitor of both 5-HT and NE.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
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