Posted by SLS on October 19, 2014, at 19:56:52
In reply to Re: PLEASE HELP: Is there some kind of dopamine issue?, posted by Joe Rogan on October 19, 2014, at 19:02:15
I think you should explore substituting Abilify for Zyprexa. It can act as a dopamine blocker or a dopamine stimulator, depending on the levels of dopamine in the synapse. Abilify has antipsychotic, antimanic, and antidepressant properties.
The nicotine thing is interesting. Perhaps your nicotinic tone is too labile. Interesingly, the metabolite of ketamine, hydroxynorketamine (HNK) blocks nicotine type 7 receptors, and has rapid and robust antidepressant properties as demonstrated in rodents. It is possible that NMDA receptor antagonism is not at all contributary to the therapeutic antidepressant effects of ketamine. In addition, HNK is 1,000 times more potent than ketamine as a stimulant of neuro-regenerative pathways. I would be first in line to try HNK in a clinical trial.
It will be important to observe you over time to see whether or not your diagnosis of schizoaffective disorder should be re-evaluated by your doctor. It might not matter too much in choosing treatments, though. A bipolar mixed-state would be treated very much the same as schizoaffective disorder. If your are schizoaffective, you might need a drug like Risperdal rather than Zyprexa. Saphris might also be effective, but without the metabolic side effects of Zyprexa and Risperdal.
- Scott-
Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1072355
URL: http://www.dr-bob.org/babble/20141017/msgs/1072525.html