Posted by SLS on October 11, 2014, at 17:55:45
In reply to Re: Does EPS put you at higher risk for TD? Worried!, posted by Christ_empowered on October 10, 2014, at 20:18:41
Nice post.
- Scott
> EPS does indicate a sensitivity that could raise the risk of TD. Also, people with mood disorders get TD more often than people with psychotic disorders. Why this is the case, I have no idea.
>
> Abilify is weird. I take it, and its great for me (I also do Orthomolecular, which may reduce the TD risk). Seroquel probably has a lower TD risk.
>
> Antipsychotics are divided by potency (more the old ones, but now the new ones, too). You have High potency, moderate potency, and low potency. High potency=less sedation, more EPS, and more TD. Like...Haldol vs Thorazine (Haldol is high potency, Thorazine low potency). Abilify is high potency (30mgs occupies something like 95% of D2 receptors), but its partial agonism reduces EPS...usually.
>
> Seroquel is low potency. Its like 21st century Thorazine, basically. Unlike Thorazine, doses that are high enough to counter psychosis, agitation, mania, etc. can also stabilize mood and often has an antidepressant quality. Thorazine and many of the older drugs were notorious for inducing or worsening depression.
>
> So...ummm...yeah. Probably too much info. I'd get off the Abilify and switch over to Seroquel/Seroquel XE. Seroquel rarely causes TD. Its used to suppress and sometimes help reverse TD caused by other antipsychotics, including some atypicals.
>
> Good luck!
>
> --Oh, and...high doses of B6 can help reverse drug induced EPS in some people, including stiff gait, tremor, akathisia, etc. Just thought I'd throw that little tid bit out there for you.
Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1072007
URL: http://www.dr-bob.org/babble/20140914/msgs/1072112.html