Re: Methylation increase or decrease transporter » linkadge

Posted by SLS on September 28, 2014, at 22:34:58

In reply to Re: Methylation increase or decrease transporter, posted by linkadge on September 28, 2014, at 20:13:27

> I wonder whether the hypermethylation increases or decreases the overall functioning of the transporter?
As I understand it, it is the methylaytion of the DNA at the promoter site of the serotonin transporter gene that determines the rate of gene expression.
Hypermethylation of the serotonin transporter gene (SLC6A4) = reduced transporter synthesis.
> I know certain antidperessants (esp citalopram and amitriptyline) have antimethylation effects.
Interesting. I guess I should look into that. Thanks.

- Scott
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I dream of things that never were and ask why not.
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Childhood adversity, serotonin, and hippocampus SLS 9/27/14
Re: Childhood adversity, serotonin, and hippocampus » SLS Phil 9/28/14
Re: Childhood adversity, serotonin, and hippocampus linkadge 9/28/14
Re: Methylation increase or decrease transporter linkadge 9/28/14
Re: Methylation increase or decrease transporter » linkadge SLS 9/28/14
Re: Methylation increase or decrease transporter Lamdage22 10/15/14

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