Posted by SLS on August 24, 2014, at 16:38:55
In reply to Buspar is *not* working for me, posted by linkadge on August 24, 2014, at 12:54:42
Guanfacine?
I mention this drug only because the buspirone metabolite, 1-PP, might have produced a hyperadrenergic state in you via NE alpha-2 receptor antagonism. Like clonidine, guanfacine is an agonist at that receptor, and may act to reduce anxiety, increase cognitive attention (ADHD), and allow for better sleep. My impression is that guanfacine is less liable than clonidine to produce depression as a side effect. I can't be sure, though.
Prazosin?
A long shot, perhaps: Prazosin might possibly reduce adrenergic tone via NE alpha-1b receptor antagonism. Speaking for myself, I react very badly to NE alpha-2 antagonists (idazoxan, mirtazapine, lurasidone). I become very much more depressed. Prazosin has an antidepressant effect on me. Perhaps there is an association. Prasosin is known to effectively treat PTSD. It helps with disturbed sleep and nightmares, and can reduce depression and anxiety during the day.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1070243
URL: http://www.dr-bob.org/babble/20140815/msgs/1070250.html