Posted by jrbecker76 on August 19, 2014, at 11:10:15
In reply to reboxetine, posted by kribensis on August 3, 2014, at 13:10:41
> I know that this is not supposed to be that effective of an AD, but I keep coming up with not only was it ineffective in trials but it might actually cause more harm than good. But I can't find what harm it causes, if any. Does anyone know? Anyone using this?
When some researchers concluded that Reboxetine "did more harm than good," this was based on the retrospective review of the original clinical trial data. Many of the negative result trials were originally unpublished. After this data was later made available, a few meta-analysis studies demonstrated that Reboxetine often times did not outperform placebo or compare to a gold-standard treatment (e.g., SSRI). In some trials, Reboxetine performed worse than placebo, so this is why it was concluded that it can sometimes "do more harm than good." This is the reason that Pfizer finally gave up on the US approval process of Reboxetine several years ago.
http://www.bmj.com/content/341/bmj.c4737.full
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC161714/
Personally speaking, Reboxetine worsened my depression. Many here on the board have unfortunately not fared well on it either. But there does seem to be a minority of sufferers that find it helpful, particularly as an augmentor.
poster:jrbecker76
thread:1069156
URL: http://www.dr-bob.org/babble/20140815/msgs/1070007.html