Posted by tom2228 on May 26, 2014, at 13:06:49
In reply to Quetiapine + Trycyclics-Interactions?, posted by BrainDamage on May 26, 2014, at 12:41:44
No, not metabolically or anything serious, but you will have some synergy.
-For both there will be additive effects on norepineprhine since norquetiapine (active metabolite of quetiapine) is an NRI like desipramine and nortriptyline
-There will be additive sedative effects with nortriptyline (histamine), as well as extra weight gain
-There will be additive effects on 5-HT2 receptors with nortriptyline, yielding antidepressant synergy and extra weight gain (5-HT2c)
-And there might be additive effects on orthostatic hypotension, dizziness when standing as all 3 drugs block alpha-1 adrenergic receptors
poster:tom2228
thread:1066157
URL: http://www.dr-bob.org/babble/20140512/msgs/1066158.html