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Re: Stablon gone bad. Psychotic symptoms back! Haldol? » Lamdage22

Posted by phidippus on May 17, 2014, at 17:16:21

In reply to Re: Stablon gone bad. Psychotic symptoms back! Haldol?, posted by Lamdage22 on May 17, 2014, at 12:12:56

What is the nature of your symptoms?

I would do the Haldol instead of Zyprexa.

Loxapine is a typical antipsychotic medication, used primarily in the treatment of schizophrenia. Trade names for loxapine taken by mouth include Loxapac and Loxitane; the inhalable form is approved as Adasuve. The drug is a member of the dibenzoxazepine class and structurally related to clozapine. Several researchers have argued that loxapine may behave as an atypical antipsychotic.
~Wikipedia
Here is its binding profile:

5-HT1A 2456
5-HT1B 388
5-HT1D 3468
5-HT1E 1399
5-HT2A 6.63
5-HT2C 13.3
5-HT3 190
5-HT5A 776
5-HT6 31.0
5-HT7 87.6
α1A 31
α1B 53
α2A 150.9
α2B 107.8
α2C 80.0
β1 >10000
β1 >10000
M1 119.5
M2 445
M3 211.3
M4 1266
M5 166
D1 54
D2 11
D3 19.33
D4 8.4
D5 75
H1 4.9
H2 208
H4 5048
SERT >10000
NET 5698
DAT >10000

There is no real advantage over Haldol.

Eric


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