Posted by klein on April 27, 2014, at 6:27:26
In reply to Re: About SSRI-induced apathy, posted by Louisiana Sportsman on April 26, 2014, at 18:04:22
> I'm sure it wasn't a placebo effect, and maybe I was grumpy.
>
> You didn't have to cite papers defining apathy and possible dopaminergic deficit. Let's cut to the chase.
>
> Any addicting behavior is going to be dopaminergic in some regard or it wouldn't be so addicting and basically glutamate/NMDA mediates the activity of a wide spectrum of assorted goodies and are essential part of how your brain is able to function.
>
> This is not news.Lousiana, I've been on a benzo for years -Klonopin first, now Valrelease- because they stabilize my mood and because sometimes I get bad anxiety (the anxiety has lessened considerable since I did CBT for a few months, so I've lowered the dosage down). I'm not addicted, I'm habituated.. bumping the dose for three days to get out of those horrible slumps isn't addictive behavior either, so far nothing else has worked.
> >
> There's one catch though, this strategy might only work for people who are already taking a regular dose of benzos due to some complicated interplay between regular benzo intake and glutmatate/NMDA, which is ultimately responsible for the dopamine boost.
> >
>
> No, it has nothing to do with benzo intake.
>
> >
> Tex's might have been right about those speculated receptors too, I'm thinking about the effect of enzos on NMDA receptors. Not to mention interneurons.
> >
>
> Which interneurons? Sounds like you're grasping for straws here.Sorry, that sounded esoteric, I was referring to the balance between GABAergic and glutamate neurons :)
> A benzodiazepine is counterintuitive to reduce apathy. It's like getting someone too drunk to care as an extreme example, it's going to end making the situation worse. Why not methylphenidate?
>My doctor won't prescribe it. I'm guessing that it could be very effective (though, except for the tretracyclics at high doses, all the stimulants I've tried have made me feel drowsy). So upping my benzos is the only solution I've found so far.
poster:klein
thread:1064752
URL: http://www.dr-bob.org/babble/20140419/msgs/1064834.html