Posted by phidippus on March 18, 2014, at 18:01:42
In reply to Re: TCAs calming vs. sedating/ nortrip vs. Saphris SLS, posted by tom2228 on March 17, 2014, at 22:17:15
> but the least anticholinergic among the TCAs?
You're still going to get anticholergenic effects.
> What would you recommend if she says no to the MAOI + TCA combo?
If she says no, try a TCA alone. I would recommend Clomipramine-especially since you suffer from obsessive ruminations.
>for nortrip the numbers are 16.5 for SERT and 1.65 for NET
Keep in mind nortryptaline:
- Boosts neurotransmitter norepinephrine/noradrenaline
- Blocks norepinephrine reuptake pump (norepinephrine transporter), presumably increasing noradrenergic neurotransmission
-Since dopamine is inactivated by norepinephrine reuptake in frontal cortex, which largely lacks dopamine transporters, nortriptyline can increase dopamine neurotransmission in this part of the brain
-A more potent inhibitor of norepinephrine reuptake pump than serotonin reuptake pump (serotonin transporter)
-At high doses may also boost neurotransmitter serotonin and presumably increase serotonergic neurotransmission> Was Invega at all calming for you? How about for agitation?
Perfect for agitation and very calming.
Eric
poster:phidippus
thread:1062693
URL: http://www.dr-bob.org/babble/20140307/msgs/1062736.html