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Re: Treating akastisia » phidippus

Posted by SLS on March 10, 2014, at 9:08:42

In reply to Re: Treating akastisia » SLS, posted by phidippus on March 10, 2014, at 8:51:00

> The buzz is akathisia is a noradranergic malfunction, so seratonin blockers don't makemuch sense to me.
>
> Eric

Not unless the serotonin receptors are actually heteroreceptors located on NE neurons. I don't know how this would work, though. It would depend upon whether akathisia is associated with NE hyper- or hypo- activity. It would also depend upon whether 5-HT heteroreceptors are excitatory or inhibitory. I haven't given this any thought. It is worth looking into, though. Perhaps the heteroreceptors suppress DA neurons or activate Ach neurons instead.

Things in the brain are ENORMOUSLY complex. Akathisia should make a good research project.


- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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