Posted by brk23 on February 23, 2014, at 2:30:17
In reply to lamictal, posted by rjlockhart37 on February 22, 2014, at 23:28:43
lamictal is horrid.Dude i know people will hate me for this but if it werent for parnate id be a sad case,cause i wont touch 95 percent of the meds out there.
Parnate however is very tricky,me and chairman maoi used to discuss this in email,parnate after its initial stimulation dies fast,HOWEVER its only cause and this is my expernce but parnate in my view from ten years of using it MUST BE AUGMENTED.
Also the doses that they recomend are absurd.They bough the drug from a lone chemisct,i read up on this,and they know little to nothing on its workings,i found this out first hand when i called once and spoke to the companys pharm tech.
Again since they bought it from a lone chemist and are not the actual creators of it,they are clueless.There is a article that states how parnate must be used,first it states the dose needs to be set high for treatment resisant cases,second the addition of a stimulant also must be used,and unlike ssris maois actualy have some sceince to it as the brain platelets of maoi inhibitation can be measured,in the study this was used to reach 80 percent inhibititation.
So to make parnate work,i promise you will need to use a higher dose then the data sheet states,usualy 60 to 90 with 120 being the high and the addition of a mild stimulant such as modfanil.
From there depending on how you feel you can also add caffiene which i found has a synergy with parnate,and klonopin goes hand in hand with parnate if your over stimulated.....here are the studies about what i spoke about,and aside from them in my own view and my girls shaslinger we both find the same to be true....
"A substantial number of depressed patients will experience a chronic, treatment-resistant affective disorder. Aggressive treatment of these patients with various drug combinations, unconventional antidepressants, or electroconvulsive therapy has met with only partial success. There remains a pressing need to identify more effective methods of utilizing "first-line" antidepressant agents to achieve a more rapid therapeutic action. To this end, we initiated a study using high doses of the MAO inhibitor tranylcypromine, at a range of 90 mg to 170 mg daily, in seven refractory depressed patients who had failed to respond to at least three prior treatments regimens. Four out of seven subjects (57%), who had failed to respond to a mean of 8 +/- 5 prior treatment, had a complete response, and one patient had a partial response to high dose tranylcypromine. The mean SD maximum tranylcypromine dose for the responders was 112 +/- 16 mg daily (range 90 mg to 130 mg). Response did not appear to be a function of severity of illness, duration of present episode, or the number of prior treatment failures. Overall, the side effect profile was favorable, and no "cheese reactions" were encountered. These observations are of clinical significance and suggest the need for further controlled studies using high doses of tranylcypromine."
http://www.ncbi.nlm.nih.gov/pubmed/2710808
p.s lamictal made me wanna hang myself dude,message me on face book well talk.
poster:brk23
thread:1061084
URL: http://www.dr-bob.org/babble/20140214/msgs/1061088.html